i have run both . this is what i have found. with stright weight oil. the oil pressure goes down 5 to 10 psi. when the motor get warmed up. and with the multi weights it stays the same. we use 10-40 in the stock car motors and they are not run in the winter.
even harley-davidson uses 20-50. the reason is when the motor is cold the thin oil pumps through it faster on start up so you dont have a dry start.
now the one thing i have been looking at is the way the oil filter is on the block of a 250. laying on its side so oil drains out of it. i think having it virtical like a v8 would help. think about it on start you have to fill the filter first.