TP:
Ok, with a guess of 4300 lb including driver I was able to get my computer to run your "250 computer engine" down the track in the "K-20 computer truck". With the 250 as you described it, I computed 4 different cams:
* Stock 250 Chev
* Comp 240H, 192/200 duration, .455/.455 lift
* PAW/SSI, 194/204 duration, .464/.490 lift
* Comp 260H, 212/212 duration, .489/.489 lift

Here is what I got for gross torq, power, and times:
Stock cam:
Torq 241 at 3100
Power 178 at 4100
For me, in a work truck like it seems you have, the most relevant time was 0-60mph, kinda the classic "street performance time. It was:
13.00 sec, 0-60mph
On the dragstrip I computed times of:
2.38 60ft
11.79 at 58.2 1/8 mile
18.72 at 70.9 1/4 mile

For the Comp 240H "192/200" duration I got:
Torq 243 at 3400
Power 196 at 4500
11.19 sec 0-60, WOW almost 2 sec faster.
2.37
11.57 at 61.3 faster in the 1/8 mile, good
18.32 at 72.3 faster in the 1/4 but so what?

For the PAW/SSI "194/204" duration I got:
Torq 244 at 3400
Power 198 at 4500
11.15 0-60mph
2.37
11.56 at 61.3
18.31 at 72.4
Either the Comp 240H or PAW 194/204 cam are a lot faster than the stocker, and no penalty down low.
Either one looks good in there.

For the Comp 260H "212/212" duration I got:
Torq 240 at 3700
Power 207 at 4800
11.23 0-60mph...SLOWER than the smaller cams....
2.41 60ft - slower.
11.56 at 62.2 - about same 1/8
18.19 at 73.0 - a little faster in the 1/4
That "Big" 260H cam isnt that big but if the truck is this heavy the smaller cams do better. And, they do a lot better than stock.

Well, this computer thing I have is home-built. It is very well wrung-out against dyno and dragstrip data - but mostly for V8's I'll admit. Inline data is harder to come by so take this info for the "free advice" it is, but it is after all computer based, only a dragstrip would tell you for sure.

If I was rebuilding your 250 for that truck, I'd get either the Comp 240H or the PAW/SSI, new lifters, probably new springs (tho I was "shifting" at 4600, pretty low.....)

good luck